Intensive Treatment of Diabetes Is Associated With a Reduced Rate of Peripheral Arterial Calcification in The Diabetes Control and Complications Trial  

Oleh:

Carter, Rickey E. ; Lackland, Daniel T. ; Cleary, Patricia A. ; Eunsil Yim ; Lopes-Virella, Maria F. ; and Others

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 30 no. 10 (Oct. 2007), page 2646.
Topik: ABI; ankle-to-brachial ratio index ; DCCT; Diabetes Control and Complications Trial ; EDIC; Epidemiology of Diabetes Interventions and Complications ; PAD; peripheral arterial disease

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2007.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Peripheral arterial disease (PAD) is a significant contributor to the morbidity and mortality of >2 million Americans (1). In addition to its own specific disease risks, PAD has been shown to be a predictor of cardiovascular mortality and coronary artery disease, as well as a general marker for the atherosclerotic disease process (2,3). PAD complications, especially in the lower limb, are significantly greater in individuals with diabetes compared with those without diabetes, and the risk imparted by diabetes is similar or greater in magnitude to that seen for ischemic heart disease and stroke (4,5). The aortofemoral arteries are prime sites for PAD; hence, determination of claudication and measurement of blood flow in the lower extremities are the most common assessments (6). A relatively low ankle systolic blood pressure (ankle-to-brachial ratio index [ABI]) has been found to be an indicator of atherosclerosis/occlusion in this region (5). Conversely, in diabetes, a high-pressure ABI due to medial wall arterial calcification and noncompressible vessels may also be associated with adverse outcomes, including diabetic kidney disease (7). Sex differences have been reported in ABI measurements in type 1 diabetes, with women having a greater frequency of low ABI and men having a higher frequency of high ABI (7). Here, we extend these analyses by examining the effect of previous intensive diabetes management on the development of abnormally high and low ABIs . . .

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali