Adiponectin Decreases Postprandially Following a Heat-Processed Meal in Individuals With Type 2 Diabetes : An effect prevented by benfotiamine and cooking method  

Oleh:

Stirban, Alin ; Negrean, Monica ; Stratmann, Bernd ; Gotting, Christian ; Salomon, Julia ; Kleesiek, Knut ; Tschoepe, Diethelm

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 30 no. 10 (Oct. 2007), page 2514.
Topik: AGE; advanced glycation end product ; HAGE; high AGE content ; LAGE; low AGE content ; TBARS; thiobarbituric acid reactive substances.

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2007.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Adiponectin regulates insulin sensitivity (1), reduces the expression of endothelial adhesion molecules (2), and has anti-inflammatory effects (3). Decreased adiponectin levels accompany obesity (4) and type 2 diabetes (5), promoting insulin resistance (5) and cardiovascular disease (6,7). Data on postprandial adiponectin regulation in different populations are controversial, with studies showing no effect (8–11), increases (12,13), or decreases (14,15). Advanced glycation end products (AGEs) (16) play a major role in the development of diabetes complications (17). We have shown that dietary AGEs acutely impair endothelial function (18,19), an effect counteracted by benfotiamine (20), a transketolase activator that blocks several hyperglycemia-induced pathways, including the formation of AGEs (21). AGEs might interact with adipocytes through AGE receptors (22) and induce cellular dysfunction via generation of reactive oxygen species (23), a pathway probably responsible for the AGE-induced downregulation of leptin secretion in vitro (24). Our study aimed at investigating the effects of a high heat–processed meal with high AGE content (HAGE) and a low heat–processed meal with low AGE content (LAGE) on postprandial adiponectin concentration. We postulated a protective effect of benfotiamine......

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali