Serum Levels of Adipokine Retinol-Binding Protein-4 in Relation to Renal Function  

Oleh:

Ziegelmeier, Michaela ; Bachmann, Anette ; Seeger, Jeannette ; Lossner, Ulrike ; Kratzsch, Jürgen ; Bluher, Matthias ; Stumvoll, Michael ; Fasshauer, Mathias

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 30 no. 10 (Oct. 2007), page 2588.
Topik: CD; chronic hemodialysis ; CRP; C-reactive protein ; FFA; free fatty acid ; GFR; glomerular filtration rate ; HOMA-IR; homeostasis model assessment of insulin resistance ; IGT; impaired glucose tolerance ; RBP; retinol-binding protein ; WHR; waist-to-hip ratio

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2007.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

OBJECTIVE—Retinol-binding protein (RBP)-4 was recently identified as an adipokine that induces insulin resistance. In the current study, we investigated RBP-4 serum levels in diabetic and nondiabetic patients on chronic hemodialysis (CD) compared with control subjects with a glomerular filtration rate >50 ml/min. The majority of the diabetic subjects used oral hypoglycemic agents or insulin. RESEARCH DESIGN AND METHODS—RBP-4 was determined by enzyme-linked immunosorbent assay in control subjects (n = 59) and CD patients (n = 58) and correlated with clinical and biochemical measures of renal function, glucose and lipid metabolism, and inflammation in both groups. RESULTS—Mean serum RBP-4 levels were almost fourfold higher in CD patients (102 ± 30 mg/l) compared with control subjects (28 ± 8 mg/l). Furthermore, serum creatinine independently predicted RBP-4 concentrations in multiple regression analyses in both control subjects and CD patients. In addition, C-reactive protein and systolic blood pressure independently and negatively correlated with RBP-4 serum concentrations in CD patients but not control subjects. In contrast, markers of glucose and lipid metabolism were not independently related to serum RBP-4 in control subjects or CD patients. CONCLUSIONS—We show that markers of renal function are independently related to serum RBP-4 levels.

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