The gut takes nearly all: threonine kinetics in infants  

Oleh:

Schoor, Sophie RD van der ; Wattimena, Darcos L. ; Huijmans, Jan ; Vermes, Andras ; Johannes B van Goudoever

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 86 no. 04 (Oct. 2007), page 1132.
Topik: Threonine ; preterm infants ; intestine ; stable isotopes ; nutrition ; splanchnic metabolism

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2007.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background:Threonine is an essential amino acid that is abundantly present in intestinally produced glycoproteins. Animal studies show that intestinal first-pass threonine metabolism is high, particularly during a restricted enteral protein intake. Objective:The objective of the study was to quantify intestinal first-pass threonine metabolism in preterm infants during full enteral feeding and during restricted enteral intake. Design:Eight preterm infants ( ± SD birth weight: 1.1 ± 0.1 kg; gestational age: 29 ± 2 wk) were studied during 2 periods. During period A, 40% of total intake was administered enterally and 60% was administered parenterally. Total threonine intake was 58 ± 6 µmol · kg–1 · h–1. During period B, the infants received full enteral feeding, and the total threonine intake was 63 ± 6 µmol · kg–1 · h–1. Dual stable-isotope tracer techniques were used to assess splanchnic and whole-body threonine kinetics. Results:The fractional first-pass threonine uptake by the intestine was remarkably high in both periods: 82 ± 6% during partial enteral feeding and 70 ± 6% during full enteral feeding. Net threonine retention was not affected by the route of feeding. Conclusion:In preterm infants, the splanchnic tissues extract a very large amount of the dietary threonine intake, which indicates a high obligatory visceral need for threonine, presumably for the purposes of synthesis.

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