SPONTANEOUS ACTIVATION OF T CELL LYMPHOCYTES IN MICE LACKING INTERLEUKIN-2 RECEPTOR B  

Oleh:

Endharti, Agustina Tri

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Jurnal Kedokteran Brawijaya vol. 23 no. 01 (Apr. 2007), page 41.
Topik: T cells; (IL2RB-/-); autoimmune

Ketersediaan

Perpustakaan FK Nomor Panggil: J34.K.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Homologous recombination applied to alter specific endogenous gene, referred as gene targeting, provides the highest level of control over product mutation in cloned genes. In this experiment we showed that by using gene targeting a knock out mutation in IL-2RB gene could be generated. The findings of this study indicated that mice lacking the Interleukin-2 receptor B chain (IL2RB-/-) had spontaneously activated. T cells. In this study, we investigated abnormal expansion of activated T cells which showed high level of CD69. These findings suggest that the IL2RB-/- mice may serve as animal model for autoimmune diseases and that the accumulation of activated T cell in the future could be used in clinical setting to cure the diseases.

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