THE LEVEL OF MDA AND GSH/GSSH RATIO IN NORMAL PREGNANCY, HEAVY PREECLAMPSIA AND ECLAMPSIA AT MALANG  

Oleh:

Candra, Siti ; Widodo, Maris ; Soetomo Suwarto ; I Ketut Muliartha G

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Jurnal Kedokteran Brawijaya vol. 23 no. 01 (Apr. 2007), page 36.
Topik: preeklamptic; MDA; GSH/GSSH ratio.

Ketersediaan

Perpustakaan FK Nomor Panggil: J34.K.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

PreeClampsia is marked by vasospasme, increasing peripheral vascular resistance and permeability, endothelial cell and reducing organ perfusion. It occurs because of the increasing of lipid hydroperoxides. The uncontrolled production of lipid hydroperoxides causes oxidative stress and destroys cell integrity. Oxidative stress condition express the increasing oxidant and decreasing antioxidant. One of the antioxidant is GSH that is used to neutralize the increasing of Malondialdehyde (MDA) level. The objective of this study was to see the difference of MDA content and GSH. GSSG ratio between the normal pregnancy, preeclamsia and eclampsia. This study was cross sectional study. The samples were 36 blood plasma consisted of 12 normal pregnancy, 12 preeclampsia and 12 eclampsia before birth. The blood plasma, was measured for its MDA level and the GSH/GSSH ratio. The result showed that the level of MDA of plasma in preeclamptic and eclamptic pregnancy were higher than normal pregnancy p=O.OOO, due to lipid peroxidation resulted from increased production of lipid hydroperoxides on preeclamptic and eclamptic pregnancy. The average of GSH/GSSH ratio in normal pregnancy is higher than preeclamptic and eclamptic plasma p=O.OO1. Decreasing the GSH/GSSH ratio might be caused by the use of GSH in neutralizing the increase of lipid hydroperoxides. There is a decrease of GSH/GSSH ratio in preeclamptic and eclamptic plasma that is used to neutralize the increasing of Malondialdehyde (MDA) content.

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