EFFECTS OF PROBIOTICS ON IMMUNE RESPONSE  

Oleh:

Djoni Djunaedi

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Jurnal Kedokteran Brawijaya vol. 23 no. 01 (Apr. 2007), page 23.
Topik: Probiotics; Intestinal Microflora; Immune Response

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Perpustakaan FK Nomor Panggil: J34.K.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Probiotics (Ufor life') is a live microbial feed supplement or defined as mono- or mixed cultures of live microorganisms which when administered in adequate amounts confer a health benefit to the host by improving its microbial balance. Common descriptives for probiotics include "friendly", "beneficial" or "healthy" bacteria. Under natural conditions a protective gut microflora develops and there is no need for probiotics supplement, but under rather un-natural conditions such like intestinal infections, post antibiotic treatment syndromes, pseudomembranous colitis, the probiotics preparations are needed. The beneficial effects of probiotics in the host are promotion of the gut maturation and integrity, antagonisms against pathogens and immune modulation. Beyond those, the microflora seems to playa significant role in diet induced superinflammation, mucosal immune system, neuroendocrine regulation, immunoglobulin production, macrophages factor restoration, apoptosis stimulation, lymphocyte function modulation, cytokine release, mucin production, intestinal immune homeostasis and inflammation prevention. However, many studies proved that probiotics have "upregulationand downregulation" effects on immune system of the host. This review article will summarize the increasing scientific attention to mechanisms of the immune response of the host towards different components of the microflora and suggest a potential role for selected probiotic bacteria in the regulation of intestinal inflammation and other diseases. Although many clinical studies with probiotics daily products demonstrating positive therapeutic effect, there is still a core question: "how regular consumption of probiotics will affect the health and the risk of infection of healthy consumers", cannot be answered at this point in time. Longterms, prospective studies are still needed.

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