Expression of cyclooxgenase-2 in head and neck squamous cel carcinoma  

Oleh:

Reksoprawiro, Sunarto ; Kipsanang Akemah ; Hoesin, Faroek

Jenis: Article from Journal - ilmiah nasional - tidak terakreditasi DIKTI
Dalam koleksi: Jurnal Ilmu Bedah Indonesia (Indonesian Journal Of Surgery) vol. 34 no. 2 (Apr. 2007), page 54.
Topik: COX-2 Espression; Squamous Cell Carcinoma; Head and Neck

Ketersediaan

Perpustakaan FK Nomor Panggil: J36.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Clnical and Papthological parameters alone are not enough to be used to predict the prognosis of the patients. There are the molecular prognostic factors such as cyclooxygenase-2 (COX-2) expression which should be considered to predict the outcome of cancer patient treatment. The purpose of this study was to determine whether COX-2 was over expressed in head and neck squalmous cell carcinoma (HNSCC). Methods : Thirty patients with HNSCC underwent surgery at Soetomo Hospital Surabaya in the period of 2004-2005 was studied. The paraffin blocks of the primary tumor were examined immunohistochemically for COX-2 expression The COX-2 expression of the specimens was graded based on the intensity of immunostaining as negative (0), weak (1), moderate (2), and strong (3). The COX-2 expression score of each specimen was ascertained as multiplication of immunostaining intensity and percentage of the stained cells. Clinical parameters of the patients were reviewed from the medical records. Results : Twenty-eight (93,3%) of the speciments showed positive COX-2 expression in immunohistochemistry staining. The percentage of the stained cells were 0-95%, and COX-2 expression score varied from 0 to 2.85 with mean of 1.27. There was no significant different between male and female, age under and upper 55 years old, intra-oral and extra-oral tumor in COX-2 expression score. Conclusion : Cyclooxygenase (COX)-2 was expressed in HNSCC (93,7% patients), the expression score was not influenced by gender, age, and location of primary tumor.

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