Tocotrienol levels in adipose tissues of bening and malignant breast lumps in patients in Malaysia  

Oleh:

Razak, Gazallabdul ; Selvaduray, Kanga Rani ; Gomez, Patricia Alison ; Nesaretnam, Kalanithi

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Asia Pacific Journal of Clinical Nutrition (keterangan: ada di Proquest) vol. 16 no. 03 (2007), page 498.
Topik: Nutritionally-Related Disorders and Disease and Their Risk factors

Ketersediaan

Perpustakaan FK Nomor Panggil: A27.K.2007.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Data on dietary exposure to vitamin E by plasma or adipose tissue concentrations of a-tocopherol (a-T) in observational studies have failed to provide consistent support for the idea that a-T provides women with any protection from breast cancer. In contrast, studies indicate that a, ?, and d-tocotrienols but not a-T have potent anti-proliferative effects in human breast cancer cells. Our aim was to investigate whether there was a difference in tocopherol and tocotrienol concentrations in malignant and benign adipose tissue, in a Malaysian population consuming predominantly a palm oil diet. The study was undertaken using fatty acid levels in breast adipose tissue as a biomarker of qualitative dietary intake of fatty acids. The major fatty acids in breast adipose tissue of patients (benign and malignant) were oleic acid (45-46%), palmitic (28-29%) and linoleic (11-12%). No differences were evident in the fatty acid composition of the two groups. There was a significant difference (p=0.006) in the total tocotrienol levels between malignant (13.7 ± 6.0 µg/g) and benign (20±6.0 µg/g) adipose tissue samples. However, no significant differences were seen in the total tocopherol levels (p=0.42) in the two groups. The study reveals that dietary intake influences adipose tissue fatty acid levels and that adipose tissue is a dynamic reservoir of fat soluble nutrients. The higher adipose tissue concentrations of tocotrienols in benign patients provide support for the idea that tocotrienols may provide protection against breast cancer.

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