The effect of n-3/ gamma-Cyclodextrin Complex on serum lipids in healthy volunteers: a randomized, placebo-controlled, double-blind trial  

Oleh:

Kobayashi, Koji ; Hamazaki, Kei ; Fujioka, Shuntaro ; Terao, Keiji ; Yamamoto, Junji ; Kobayashi, Satoru

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Asia Pacific Journal of Clinical Nutrition (keterangan: ada di Proquest) vol. 16 no. 03 (2007), page 429.
Topik: Macro- Micro- and Phyto-nutrients

Ketersediaan

Perpustakaan FK Nomor Panggil: A27.K.2007.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objectives: This study was carried out to examine whether serum triglyceride concentrations were decreased by administration of n–3 polyunsaturated fatty acid (PUFA)/?-cyclodextrin (?-CD) complex-containing capsules as reported previously with n–3 PUFA without ?-CD. Study Design: A placebo-controlled double-blind study with healthy subjects (n=35) and hypertriglyceridemic subjects (n=7) of 35-66 years of age was performed. The subjects were randomized to a group (n–3 group) supplemented with n–3 PUFA/?-CD-containing capsules (660 mg EPA + 280 mg DHA/day) or a control group supplemented with capsules containing essentially no n–3 PUFA for 8 weeks with stratification by sex, age, and serum triglyceride levels in a double blind manner. Fasting blood samples were obtained at the start of administration and 4 and 8 weeks afterward. Results: EPA concentrations in the total phospholipid fraction of red blood cells increased significantly in all subjects in the n–3 group, whereas no changes were seen in the control group. Triglyceride levels were significantly decreased (–17%) in the n–3 group compared with the control group at week 8. The following serum lipids did not significantly change over time: total-cholesterol, low-density lipoprotein-cholesterol and high-density lipoprotein-cholesterol. Only two subjects in the n–3 group guessed at the end of the study that their capsules were active. Conclusion: n–3 PUFA/?-CD complex lowered triglyceride levels in normal and slightly hypertriglyceridemic subjects. There was a possibility that ?-CD might at least partly cover the smell and aftertaste of fish oil.

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