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High Prevalence of goiter in a iodine replete area: do tyroid auto-antibodies play a role?
Oleh:
Hashemipur, Mahin
;
Amini, Masoud
;
Aminorroaya, Ashraf
;
Rezvanian, Hassan
;
Kochoei, Ali
;
and Others
Jenis:
Article from Journal - ilmiah internasional
Dalam koleksi:
Asia Pacific Journal of Clinical Nutrition (keterangan: ada di Proquest) vol. 16 no. 03 (2007)
,
page 403.
Topik:
Nutritional Pathophysiology
Ketersediaan
Perpustakaan FK
Nomor Panggil:
A27.K.2007.02
Non-tandon:
1 (dapat dipinjam: 0)
Tandon:
tidak ada
Lihat Detail Induk
Isi artikel
Introduction: Despite long standing iodine supplementation in Iran the prevalence of goiter remains high in some areas. This may suggest that causes other than iodine deficiency, such as autoimmune thyroid diseases, should also be considered. We therefore assessed the prevalence of anti-thyroid antibodies in children living in an inland area in Iran and correlated these findings with prevalence of goiter within this region. Methods: In a cross-sectional study, 1948 students were selected by multistage random cluster sampling from the 108 primary schools (age, 7-13 year-old) of the urban and rural areas of Semirom. After obtaining written consent from their parents, the children were examined by endocrinologists for goiter grading. Grade 2 goitrous children (108 cases) were compared with non-goitrous children (111 children as control group) for anti-thyroid antibodies. Results: Overall, 36.7% of 1948 students had goiter. The mean urinary iodine excretion level was 1.49±0.7 µmol/L. This was within normal limits. Of 219 children studied, 4.3% presented with subclinical hypothyroidism, and 7.3% had positive anti-thyroid antibodies. There was non-significant difference of positive thyroperoxidase antibody (anti-TPO) (Odds Ratio= 3.2, p= 0.13) but significant difference of anti Tg between goitrous and non goitrous children (Odds Ratio: 5.6, 95% CI: 1.18-26.0, p: 0.015). Conclusion: This study suggests that autoimmunity may be one of the mechanisms responsible for goiter persistence after iodine replenishment in this iodine deficient region, but the role of other factors should also be considered.
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