Unresolved question in managing hypothyroidism during pregnancy  

Oleh:

Glinoer, Daniel ; Abalovich, Marcos

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: British Medical Journal (keterangan: ada di Proquest) vol. 335 no. 7614 (Aug. 2007), page 300.
Topik: Practice

Ketersediaan

Perpustakaan FK Nomor Panggil: B16.K.2007.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Introduction Diagnosing and managing hypothyroidism during pregnancy can be problematic. The scenario box on this page illustrates some typical problems encountered and raises pertinent questions concerning good medical practice. In this article, we define autoimmune thyroiditis as the presence of measurable circulating antithyroid autoantibodies (to thyroglobulin or thyroperoxidase), irrespective of abnormalities of thyroid function. Subclinical hypothyroidism is defined as an increase in serum thyroid stimulating hormone (TSH; usually 4-10 mU/l) associated with normal concentrations of serum thyroxine and triiodothyronine. Overt hypothyroidism is defined as an increase in serum TSH (usually >10 mU/l) associated with a decreased concentration of thyroxine, as a result of negative feedback; at that stage, most patients have symptoms and benefit from treatment. SCENARIO Mrs SC, aged 29 years, has a family history of goitre. Nine months after a first delivery in 1999, she had positive antithyroid peroxidase antibodies and a serum thyroid stimulating hormone (TSH) concentration of 3.1 . . .

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