Non-transcriptional control of DNA replication by c-Myc  

Oleh:

Dominguez-Sola, David ; Ying, Carol Y. ; Grandori, Carla ; Ruggiero, Luca ; Chen, Brenden ; Li, Muyang ; Galloway, Denise A ; Gu, Wei ; Gautier, Jean ; Dalla-Favera, Riccardo

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: NATURE (keterangan: ada di Proquest) vol. 448 no. 7152 (Jul. 2007), page 445.

Ketersediaan

Perpustakaan FK Nomor Panggil: N01.K.2007.07 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

The c-Myc proto-oncogene encodes a transcription factor that is essential for cell growth and proliferation and is broadly implicated in tumorigenesis. However, the biological functions required by c-Myc to induce oncogenesis remain elusive. Here we show that c-Myc has a direct role in the control of DNA replication. c-Myc interacts with the pre-replicative complex and localizes to early sites of DNA synthesis. Depletion of c-Myc from mammalian (human and mouse) cells as well as from Xenopus cell-free extracts, which are devoid of RNA transcription, demonstrates a non-transcriptional role for c-Myc in the initiation of DNA replication. Overexpression of c-Myc causes increased replication origin activity with subsequent DNA damage and checkpoint activation. These findings identify a critical function of c-Myc in DNA replication and suggest a novel mechanism for its normal and oncogenic functions.

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