Chromatin dynamics and the preservation of genetic information  

Oleh:

Downs, Jessica A ; Nussenzweig, Michel C. ; Nussenzweig, Andre

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: NATURE (keterangan: ada di Proquest) vol. 447 no. 7147 (Jun. 2007), page 951.

Ketersediaan

Perpustakaan FK Nomor Panggil: N01.K.2007.06 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

The integrity of the genome is frequently challenged by double-strand breaks in the DNA. Defects in the cellular response to double-strand breaks are a major cause of cancer and other age-related pathologies; therefore, much effort has been directed at understanding the enzymatic mechanisms involved in recognizing, signalling and repairing double-strand breaks. Recent work indicates that chromatin — the fibres into which DNA is packaged with a proteinaceous structural polymer — has an important role in initiating, propagating and terminating this cellular response to DNA damage.

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