Variations in the preproghrelin gene correlate with higher body mass index, fat mass, and body dissatisfaction in young Japanese women  

Oleh:

Ando, Tetsuya ; Ichimaru, Yuhei ; Shoji, Masayasu ; Komaki, Gen

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 86 no. 01 (Jul. 2007), page 25.
Topik: Obesity and eating disorders.

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2007.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: Ghrelin is an endogenous peptide that stimulates growth hormone secretion, enhances appetite, and increases body weight and may play a role in eating disorders. Objective: The purpose was to determine whether any preproghrelin gene variants are associated with anthropometric measures, circulating ghrelin, lipid concentrations, insulin resistance, or psychological measures relevant to eating disorders in young women. Design: This cross-sectional study compared outcome measures between preproghrelin genotypes. The participants in the study included 264 Japanese women [university students with a mean (±SD) age of 20.4 ± 0.7] with no history of eating disorders. The main outcomes were responses to the Eating Disorder Inventory-2 (EDI-2), anthropometric measures, measures of depression and anxiety, and fasting blood concentrations of acylated or desacyl ghrelin, lipids, glucose, and insulin. Results: Two single nucleotide polymorphisms (SNPs) whose minor allele frequencies were >0.05—the Leu72Met (408 CA) SNP in exon 2 and the 3056 TC SNP in intron 2—were used for association analysis. The 3056C allele was significantly associated with a higher acylated ghrelin concentration (P = 0.0021), body weight (P = 0.011), body mass index (P = 0.007), fat mass (P = 0.012), waist circumference (P = 0.008), and skinfold thickness (P = 0.011) and a lower HDL-cholesterol concentration (P = 0.02). Interestingly, the 3056C allele was related to elevated scores in the Drive for Thinness–Body Dissatisfaction (DT-BD) subscale of the EDI-2 (P = 0.003). Conclusion: Our findings suggest that the preproghrelin gene 3056TC SNP is associated with changes in basal ghrelin concentrations and physical and psychological variables related to eating disorders and obesity.

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