Preeclampsia Risk in Women Exposed in Utero to Diethylstilbestrol  

Oleh:

Troisi, Rebecca ; Titus-Ernstoff, Linda ; Hyer, Marianne ; Hatch, Elizabeth E. ; Robboy, Stanley J. ; Strohsnitter, William ; Palmer, Julie R. ; Oglaend, Bjorn ; Adam, Ervin ; Kaufman, Raymond ; Herbst, Arthur L. ; Hoover, Robert N

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Obstetrics and Gynecology vol. 110 no. 01 (Jul. 2007), page 113.

Ketersediaan

Perpustakaan FK Nomor Panggil: O01.K.2007.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

From the 1Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland; 2Department of Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 3Information Management Services Inc, Rockville, Maryland; 4Department of Epidemiology and Biostatistics, Boston University School of Public Health, Boston, Massachusetts; 5Pathology Department, Duke University Medical Center, Durham, North Carolina; 6Department of Obstetrics and Gynecology, New England Medical Center, Boston, Massachusetts; 7Slone Epidemiology Unit, Boston University, Boston, Massachusetts; 8Division of Gynaecology, Obstetrics and Paediatrics, Stavanger University Hospital, Stavanger, Norway; 9Obstetrics and Gynecology Physicians Organization, Methodist Hospital, Houston, Texas; and 10Department of Obstetrics and Gynecology, University of Chicago, Chicago, Illinois. OBJECTIVE: To assess whether preeclampsia risk is elevated in pregnancies of diethylstilbestrol (DES)-exposed daughters. METHODS: This study used data from the National Cancer Institute DES Combined Cohorts Follow-up Study. A total of 285 preeclampsia cases (210 exposed and 75 unexposed) occurred in 7,313 live births (4,759 DES exposed and 2,554 unexposed). Poisson regression analysis estimated relative risks and 95% confidence intervals (CI) for preeclampsia adjusted for age at the index pregnancy, parity, education, smoking, body mass index, year of diagnosis, and cohort. RESULTS: In utero DES exposure was associated with nearly a 50% elevation in preeclampsia risk. Adjustment for preeclampsia risk factors attenuated the relative risk slightly (1.42, 95% CI 1.04–1.94). The excess risk with DES was concentrated among women who developed preeclampsia in their first pregnancies (relative risk 1.81, 95% CI 1.17–2.79), who were exposed before 15 weeks of gestation (relative risk 1.57, 95% CI 1.11–2.23), and who were treated with magnesium sulfate (relative risk 2.10, 95% CI 0.82–5.42). Among DES-exposed women who had a prior hysterosalpingogram, preeclampsia prevalence was higher in those with uterine abnormalities (12.4%) than in those without (7.7%). CONCLUSION: These data suggest that in utero exposure to DES is associated with a slightly elevated risk of preeclampsia, and that one possible biological mechanism involves uterine abnormalities.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali