Exposure to Diethylstilbestrol: Design of a Multilevel Community Intervention  

Oleh:

Duke, Suzanne S. ; McGraw, Sarah A. ; Avis, Nancy E.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Health Promotion Practice vol. 1 no. 2 (Apr. 2000), page 188-195.
Fulltext: 188HPP12.pdf (59.73KB)

Isi artikel

Diethylstilbestrol (DES), a synthetic estrogen, was prescribed to pregnant women as early as 1938. Based on limited clinical observations and speculation about its biochemical mechanisms, prescription of DES was adopted by physicians in many areas of the country under the erroneous expectation that it would prevent miscarriage and produce a healthier pregnancy (Guisti, Iwamoto,&Hatch, 1995; Wingard, Cohn, Helmrich,& Edelstein, 1996). Although no beneficial effect was observed in a large clinical trial reported in 1953 (Dieckmann, Davis, Rynkiewicz, & Pottinger, 1953), DES during pregnancy continued to be prescribed.

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