Perbedaan Respons antara Pemakai Clopidogrel dengan Asam Asetilsalisilat terhadap Agregasi Trombosit in Vitro  

Oleh:

Suromo, Lisyani B.

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI - non-atma jaya
Dalam koleksi: Media Medika Indonesiana vol. 41 no. 03 (Nov. 2006), page 118.
Topik: Clopidogrel; ASA; response in PAT

Ketersediaan

Perpustakaan FK Nomor Panggil: M30.K.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The difference of platelet aggregation in vitro between clopidogrel and acetylsalicylic acid consumers Background: Clopidogrel and acetylsalicylic acid (ASA) are commonly used to prevent atherosclerotic complications. Clinical trials had been reported in comparing the effects of cIopidogrel and ASA (e.g.cIopidogrel versus aspirin in patient at risk of ischaemic events). Study about the different of platelet aggregation in vitro between those drugs have not yet been conducted. The aim ofthis study was to evaluate the difference of platelet aggregation in vitro between clopidogrel and ASA consumers at risk of atherosclerosis. Methods: A cross sectional study had been conducted with 2 groups: clopidogrel (dosage: 'Y2-1 tablet a 75 mg/day) and ASA (dosage: 80-100 mg/day) consumers. Thirty samples/group were taken consequtively. Inclusion criterias: men and women, age ~ 40years old, suffered from or had risk of cardiovascular disease, ambulatory patients, taking cIopidogrel or ASA ?1month-1year, normal physical and psychological activities, not consuming: other drugs, foods, beverages which would influence the platelet function. Whole blood specimens were examined using the platelet aggregation test of Born's method (PACKS 4). Ten uM of adenosine diphosphate was used as an inductor. The mean value of % maximal aggregation and aggregation responses were evaluated using t-independent and Pearson Chi-Square tests. Results: Maximal aggregations of clopidogrel consumers: ASA and IK were 49,3r.18,22 max%; 65,5r. 13,09 max% (p=O,OOO; 7.982, 24.378) respectively. Hypoaggregation responses were found in 25 clopidogrel and 19A5A consumers (p= 0,080). Conclusions: There is a difference in in vitro response of thrombocytes maximal aggregation between cIopidogrel and ASA users, nut not in hypoaggregation response.

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