Exploiting the defensive sugars of HIV-l for drug and vaccine design  

Oleh:

Scanlan, Christopher N. ; Offer, John ; Zitzmann, Nicole ; Dwek, Raymond A

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: NATURE (keterangan: ada di Proquest) vol. 446 no. 7139 (Apr. 2007), page 1038.
Topik: Glycochemistry dan Glycobiology

Ketersediaan

Perpustakaan FK Nomor Panggil: N01.K.2007.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The sustained effort towards developing an antibody vaccine against HIV/AIDS has provided much of our understanding of viral immunology. It is generally accepted that one of the main barriers to antibody neutralization of HIV is the array of protective structural carbohydrates that covers the antigens on the virus's surface. Intriguingly, however, recent findings suggest that these carbohydrates, which have evolved to protect HIV and promote its transmission, are also attractive therapeutic targets

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