Oral use of Swedish moist snuff (snus) and risk for cancer of the mouth, lung, and pancreas in male construction workers: a retrospective cohort study  

Oleh:

Luo, Juhua ; Weimin Ye ; Zendehdel, Kazem ; Adami, Johanna ; Adami, Hans-Olov ; Boffetta, Paolo ; Nyren, Olof

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Lancet (keterangan: ada di Proquest) vol. 369 no. 9578 (Jun. 2007), page 2015.

Ketersediaan

Perpustakaan FK Nomor Panggil: L01.K.2007.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Summary Background Although classified as carcinogenic, snuffis used increasingly in several populations. Scandinavian moist snuff (snus) has been proposed as a less harmful alternative to smoking, but precise data on the independent associations of snus use with site-specific cancers are sparse. We aimed to assess the risks for cancer of the oral cavity, lung, and pancreas. Methods Detailed information about tobacco smoking and snus use was obtained from 279897 male Swedish construction workers in 1978-92. Complete follow-up until end of 2004 was accomplished through links with I population and health registers. To distinguish possible effects of snus from those of smoking, we focused on I 125576 workers who were reported to be never-smokers at entry. Adjusted relative risks were derived from Cox: proportional hazards regression models. Interpretation Use of Swedish snus should be added to the list of tentative risk factors for pancreatic cancer. We were unable to confirm any excess of oral or lung cancer in snus users.

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