Curcumin protects against failure to generate a transmembrane potential and protein aggregation of rat liver mitochondria induced by tertbutylhydroperoxides  

Oleh:

Suyatna, Fransiscus D. ; Setiawati, A. ; Susilowati, S.

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Medical Journal of Indonesia vol. 16 no. 03 (Jul. 2007), page 139.
Topik: Keywords: curcumin; t-BuOOH; mitochondria; transmembrane potential; protein electrophoresis.

Ketersediaan

Perpustakaan FK Nomor Panggil: M35.K.2007.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Curcumin, an active ingredient of curcuma plant has been thought to be beneficial in the treatment of liver diseases. In the previous studies, we have shown the protective effects of curcumin against lipid peroxidation and swelling of the rat liver mitochondrial preparation induced by tert-butylhydroperoxide (t-BuOOH). In the present study, the administration oft-BuOOH of 90 pM caused the mitochondria failed to generate a transmembrane potential ('ltn). Of 3 doses of curcumin administered (0.5 uM, 2.5 uM dan 5.0 uM) the maximum protective effect against failure to generate a transmembrane potential caused by t- BuOOH was obtained by 2.5 uM of curcumin (79.13+- 6.28%). Further, curcumin of 1000 uM could prevent protein aggregation formation caused by t-BuOOH in the electrophoretogram. This study shows the protective effects of curcumin against damaged of energy production system and protein of the mitochondria caused by t-BuOOH.

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