Detail A COmmon Allele on Chromosome 9 Associated with Coronary Heart Disease   Oleh:  McPherson, Ruth ; Pertsemlidis, Alexander ; Kavaslar, Nihan ; Stewart, Alexandre ; Roberts, Robert ; Cox, David R. ; Hinds, David A. ; Pennacchio, len A. ; Tybjaerg-Hansen, Anne ; Folsom, Aaron R ; Boerwinkle, Eric ; Hobbs, Helen H ; Cohen, Jonathan C Jenis: Article from Bulletin/Magazine Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 316 no. 5830 (Jun. 2007), page 1488. Ketersediaan Perpustakaan FK Nomor Panggil: S01.K.2007.06 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel Coronary heart disease (CHD) is a major cause of death in Western countries. We used genomewide association scanning to identify a 58-kilobase interval on chromosome 9p21 that was consistently associated with CHD in six independent samples (more than 23,000 participants) from four Caucasian populations. This interval, which is located near the CDKN2A and CDKN28 genes, contains no annotated genes and is not associated with established CHD risk factors such as plasma lipoproteins, hypertension, or diabetes. Homozygotes for the risk allele make up 20 to 25% of Caucasians and have a -30 to 40% increased risk of CHD. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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