Detail Regulation of CD8+ T Cell Development by Thymus-Specific Proteasomes   Oleh:  Murata, Shigeo ; Sasaki, Katsuhiro ; Kishimoto, Toshihiko ; Niwa, Shin-Ichiro ; Hayashi, Hidemi ; Takahama, Yousuke ; Tanaka, Keiji Jenis: Article from Bulletin/Magazine Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 316 no. 5829 (Jun. 2007), page 1349. Ketersediaan Perpustakaan FK Nomor Panggil: S01.K.2007.06 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel Proteasomes are responsible for generating peptides presented by the class I major histocompatibility complex (MHC) molecules of the immune system. Here, we report the identification of a previously unrecognized catalytic subunit called B5t. B5t is expressed exclusively in cortical thymic epithelial cells, which are responsible for the positive selection of developing thymocytes. Although the chymotrypsin-like activity of proteasomes is considered to be important for the production of peptides with high affinities for MHC class I clefts, incorporation of B5t into proteasomes in place of B5 or B5i selectively reduces this activity. We also found that ~5t-deficient mice displayed defective development of C08+ T cells in the thymus. Our results suggest a key role for B5t in generating the MHC class l-restricted C08+ T cell repertoire during thymic selection. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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