Detail Reconstitution of DNA Segregation Driven by Assembly of a Prokaryotic Actin Homolog   Oleh:  Garner, Ethan C. ; Campbell, Christopher S ; Weibel, Douglas B ; Dyche Mullins, R Jenis: Article from Bulletin/Magazine Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 315 no. 5816 (Mar. 2007), page 1270. Topik: Cell Biology Ketersediaan Perpustakaan FK Nomor Panggil: S01.K.2007.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel Multiple unrelated polymer systems have evolved to partition DNA molecules between daughter cells at division. To better understand polymer-driven DNA segregation, we reconstituted the threecomponent segregation system of the Rl plasmid from purified components. We found that the ParR/parC complex can construct a simple bipolar spindle by binding the ends of ParM filaments, inhibiting dynamic instability, and acting as a ratchet permitting incorporation of new monomers and riding on the elongating filament ends. Under steady-state conditions, the dynamic instability of unattached ParM filaments provides the energy required to drive DNA segregation. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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