Detail Nuclear Actin Regulates Dynamic Subcellular Localization and Activity of the SRF Cofactor MAL   Oleh:  Vartiainen, Maria K. ; Guettler, Sebastian ; Larijani, Banafshe ; Treisman, Richard Jenis: Article from Bulletin/Magazine Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 316 no. 5832 (Jun. 2007), page 1749. Ketersediaan Perpustakaan FK Nomor Panggil: S01.K.2007.06 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel Actin, which is best known as a cytoskeletal component, also participates in the control of gene expression. We report a function of nuclear actin in the regulation of MAL, a coactivator of the transcription factor serum response factor (SRF). MAL, which binds monomeric actin, is cytoplasmic in many cells but accumulates in the nucleus upon serum-induced actin polymerization. MAL rapidly shuttles between cytoplasm and nucleus in unstimulated cells. Serum stimulation effectively blocks MAL nuclear export, which requires MAL-actin interaction. Nuclear MAL binds SRF target genes but remains inactive unless actin binding is disrupted. Fluorescence resonance energy transfer analysis demonstrates that the MAL-actin interaction responds to extracellular signals. Serum-induced signaling is thus communicated to nuclear actin to control a transcriptional regulator. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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