Detail Autophagy-Dependent Viral Recognition by Plasmacytoid Dendritic Cells   Oleh:  Lee, Heung Kyu ; Lund, Jennifer M. ; Ramanathan, Balaji ; Mizushima, Noboru ; Iwasaki, Akiko Jenis: Article from Bulletin/Magazine Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 315 no. 5817 (Mar. 2007), page 1398. Ketersediaan Perpustakaan FK Nomor Panggil: S01.K.2007.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel Plasmacytoid dendritic cells (pDCs) detect viruses in the acidified endosomes by means of Toll-like receptors (TLRs). Yet, pDC responses to certain single-stranded RNA (ssRNA) viruses occur only after live viral infection. We present evidence here that the recognition of such viruses by TLR7 requires transport of cytosolic viral replication intermediates into the lysosome by the process of autophagy. In addition, autophagy was found to be required for the production of interferon-a by pDCs. These results support a key role for autophagy in mediating ssRNA virus detection and interferon-a secretion by pDCs and suggest that cytosolic replication intermediates of viruses serve as pathogen signatures recognized by TLR7. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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