Effect of zinc supplementation on mortality in children aged 1-48 months: a community-based randomised placebocontrolled trial  

Oleh:

Sazawal, Sunil ; Black, Robert E. ; Ramsan, Mahdi ; Chwaya, Hababu M ; Dutta, Arup ; Dhingra, Usha ; Stoltzfus, Rebecca J ; Othman, Mashavi K. ; Kabole, Fatma M

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Lancet (keterangan: ada di Proquest) vol. 369 no. 9565 (Mar. 2007), page 927.

Ketersediaan

Perpustakaan FK Nomor Panggil: L01.K.2007.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Summary Background Studies from Asia have suggested that zinc supplementation can reduce morbidity and mortality in children, but evidence from malarious populations in Africa has been inconsistent Our aim was to assess the effects of zinc supplementation on overall mortality in children in Pemba, Zanzibar. Methods We enrolled 42 546 children aged 1-36 months, contributing a total of 56507 child-years in a randomised, double-blind, placebo-controlled trial in Pemba, Zanzibar. Randomisation was by household. 21274 children received daily supplementation with zinc 10 mg (5 mg in children younger than 12 months) for mean 484.7 days (SD 306.6). 21272 received placebo. The primary endpoint was overall mortality, and analysis was by intention to treat. This study is registered as an International Standard Randomised Clinical Trial, number ISRCTN59549825. Findings Overall, there was a non-significant 7% (95% CI -6% to 19%; p=O. 29) reduction in the relative risk of allcause mortality associated with zinc supplementation.

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