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Protein Composition of Catalytically Active Human Telomerase from Immortal Cells
Oleh:
Cohen, Scott B
;
Graham, Mary E.
;
Lovrecz, George o.
;
Bache, Nicolai
;
Robinson, Phillip J.
;
Reddel, Roger R.
Jenis:
Article from Bulletin/Magazine
Dalam koleksi:
SCIENCE (keterangan: ada di Proquest) vol. 315 no. 5820 (Mar. 2007)
,
page 1850.
Ketersediaan
Perpustakaan FK
Nomor Panggil:
S01.K.2007.03
Non-tandon:
1 (dapat dipinjam: 0)
Tandon:
tidak ada
Lihat Detail Induk
Isi artikel
Telomerase is a ribonucleoprotein enzyme complex that "adds 5'-TTAGGG-3' repeats onto the ends of human chromosomes, providing a telomere maintenance mechanism for -90% of human cancers. We have purified human telomerase -lOB-fold, with the final elution dependent on the enzyme's ability to catalyze nucleotide addition onto a DNA oligonucleotide of telomeric sequence, thereby providing specificity for catalytically active telomerase. Mass spectrometric sequencing of the protein components and molecular size determination indicated an enzyme composition of two molecules each of telomerase reverse transcriptase, telomerase RNA, and dyskerin.
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