Detail Computational Design of Peptides That Target Transmembrane Helices   Oleh:  Vin, Hang ; Slusky, Joanna S. ; Berger, Bryan W ; Walters, Robin S. ; Vilaire, Gaston ; Litvinov, Rustem I. ; Lear, James D. ; Caputo, Gregory A ; Bennett, Joel S ; DeGrado, William F. Jenis: Article from Bulletin/Magazine Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 315 no. 5820 (Mar. 2007), page 1817. Ketersediaan Perpustakaan FK Nomor Panggil: S01.K.2007.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel A variety of methods exist for the design or selection of antibodies and other proteins that recognize the water-soluble regions of proteins; however, companion methods for targeting transmembrane (TM) regions are not available. Here, we describe a method for the computational design of peptides that target TM helices in a sequence-specific manner. To illustrate the method, peptides were designed that specifically recognize the TM helices of two closely related integrins (allb~3 and Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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