Treatment of Periodontitis and Endothelial Function  

Oleh:

Tonetti, Maurizio S. ; D'Aiuto, Francesco ; Nibali, Luigi ; Storry, Ann Donald Clare ; Parkar, Mohamed ; Suvan, Jean ; Hingorani, Aroon D ; Vallance, Patrick ; Deanfield, John

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 356 no. 09 (Mar. 2007), page 911.

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2007.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

BACKGROUND Systemic inflammation may impair vascular function, and epidemiologic data sug- f gest a possible link between periodontitis and cardiovascular disease. METHODS We randomly assigned 120 patients with severe periodontitis to community-based periodontal care (59 patients) or intensive periodontal treatment (Gl). Endothelial: function, as assessed by measurement of the diameter of the brachial artery during, flow (flow-mediated dilatation), and inflammatory biomarkers and markers of coagulation and endothelial activation were evaluated before treatment and 1, if, 30, GO, and 180 days after treatment. RESULTS Twenty-four hours after treatment, flow-mediated dilatation was significantly lower ( in the intensive-treatment group than in the control-treatment group (absolute difference, 1.4%; 95% confidence interval [CI], 0.5 to 2.3; P=0.002), and levels of C-reactive protein, interleukin-G, and the endothelial-activation markers soluble E-selectin and von Willebrand factor were significantly higher (P<0.05 for all comparisons). However, flow-mediated dilatation was greater and the plasma levels of soluble E-selectin were lower in the intensive-treatment group than in the controltreatment group GO days after therapy (absolute difference in flow-mediated dilatation, 0.9%; 95% CI, 0.1 to 1.7; P=0.02) and 180 days after therapy (difference, 2.0%; 95% CI, 1.2 to 2.8; P

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