Microbicide drug candidates to prevent HIV infection  

Oleh:

Balzarini, Jan ; Damme, Lut van

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Lancet (keterangan: ada di Proquest) vol. 369 no. 9563 (Mar. 2007), page 787.

Ketersediaan

Perpustakaan FK Nomor Panggil: L01.K.2007.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

25 years after the first HIV/AIDS cases emerged'in 1981, the disease continues to spread worldwide, with about I 15000 new infections every day. Although highly active antiretroviral therapy (HAART) has greatly reduced the rate of I HIV infection, and the spread of the epidemic, this effect has largely been seen in developed countries. More than I 90% of HIV-infected people live in developing countries, most of whom do not have access to this treatment. The I development of efficient, widely available, and low-cost microbicides (gels and creams can be applied topically before sex) to prevent sexually transmitted HIV infections should be given high priority. We review different categories of : microbicide drugs and lead compounds, their mechanism of action, current status of development, and progress in I phase III trials.

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