Inheritance of a Cancer-Associated MLHI Germ-Line Epimutation  

Oleh:

Hitchins, Megan P ; Wong, Justin J.L ; Suthers, Graeme ; Suter, Catherine M. ; Martin, David I.K. ; Hawkins, Nicholas J. ; Ward, Robyn L

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 356 no. 07 (Feb. 2007), page 697.

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2007.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Persons who have hypermethylation of one allele of MLHI in somatic cells throughout the body (a germ-line epimutation) have a predisposition for the development of cancer in a pattern typical of hereditary nonpolyposis colorectal cancer. By studying the families of two such persons, we found evidence that the epimutation was transmitted from a mother to her son but was erased in his spermatozoa. The affected maternal allele was inherited by three other siblings from these two families, but in those offspring the allele had reverted to the normal active state. These findings demonstrate a novel pattern of inheritance of cancer susceptibility and are consistent with transgenerational epigenetic inheritance.

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